Povidone Iodine Platform Technology

Povidone iodine (PVP-I) is a complex of polyvinylpyrrolidone and iodine. It is also called iodophor and contains 9-12% effective iodine. It is a powerful disinfectant with a broad spectrum of applications and is highly effective against viruses, bacteria, fungi, and mold spores. It causes little irritation on skin and has low toxicity and a long lasting effect, and can be used safely and easily. It basically does not cause irritation on tissue and is widely used for skin and mucous membrane disinfection, e.g., for pre-surgical cleaning and disinfection of surgical sites and wounds.

The principle of sterilization is mainly through the release of hydrated iodine which has a bactericidal effect. Povidone is hydrophilic and can carry iodine to the cell membrane. When the complex arrives at the cell wall, the iodine is released and complexes with amino acids of bacterial proteins to denature them and, at the same time, oxidizes the active groups of the bacteria’s protoplasmic protein so that the bacteria dies rapidly.

Povidone iodine is a very good bactericidal agent with no antibiotic resistance. In common use, povidone iodine’s concentration is between 0.1% and 10%. Current povidone iodine preparations are in the forms of gel, suppository, cream and solution, with concentrations ranging from 1% to 10%.

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